How Tresiba® works
A different molecular design

Injection
Prior to injection, Tresiba® exists as dihexamers inside the pen in the presence of zinc and phenol1

Assembly
After injection, phenol diffuses and Tresiba® dihexamers assemble and form multihexamer chains, resulting in a subcutaneous insulin depot1

Absorption
Zinc diffuses and insulin monomers are released slowly from the ends of the chains and are absorbed continuously from the depot into circulation1

See how once-daily Tresiba® works
Tresiba® has a different insulin molecule that provides a steady rate of absorption, giving it a long duration of action. Experience the mechanism of protraction by watching the animated video below.1,2