A smooth and steady release provides continuous coverage for longer than 24 hours
Tresiba® is the only basal insulin indicated for patients 1 year and older with diabetes1-5
A flat, stable profile1,6,7
42+ hour duration of action1
Provides a long duration of action that won’t taper off at the end of the day1,6,a
Tresiba® FlexTouch® U-100 pen and vial
Available in a prefilled insulin pen with no push-button extension and a multiple-dose, 10-mL vial

aAfter the last of 8 once-daily injections (0.4 units/kg).
If a pediatric patient misses a dose, they should contact their health care provider for guidance and monitor blood glucose levels more frequently until the next scheduled dose. Adult patients who miss a dose of Tresiba® should inject their daily dose during waking hours upon discovering the missed dose, then continue with their regular dosing schedule. Ensure that at least 8 hours have elapsed between Tresiba® injections.1
Population pharmacokinetic analysis was conducted for Tresiba® using data from 199 pediatric subjects (1 to <18 years of age) with type 1 diabetes. Body weight was a significant covariate affecting the clearance of Tresiba®. After adjusting for body weight, the total exposure of Tresiba® at steady state was independent of age.
The safety and effectiveness of Tresiba® to improve glycemic control in type 1 and type 2 diabetes have been established in pediatric patients 1 year of age and older. The safety and effectiveness of Tresiba® have not been established in pediatric patients less than 1 year old. The use of Tresiba® in pediatric patients 1 year of age and older with type 1 and type 2 diabetes is supported by evidence from an adequate and well-controlled study and a pharmacokinetic study (studies included pediatric patients 1 year of age and older with type 1 diabetes mellitus). The use of Tresiba® in pediatric patients 1 year of age and older with type 2 diabetes is also supported by evidence from adequate and well-controlled studies in adults with type 2 diabetes.

Start your pediatric patients on Tresiba® now
Start your pediatric patients on Tresiba® now
Tresiba® FlexTouch® is a prefilled insulin pen with no push-button extension
Standard insulin pen

Tresiba® FlexTouch® U-100


No matter what dose is dialed, the Tresiba® FlexTouch® U‑100 push button doesn’t extend any higher.

Contains 300 total units

Maximum dose of 80 units in a single injection

1-unit dose increments
After opening, Tresiba® may be used for up to 8 weeks when kept at room temperature or in the refrigerator vs 4 weeks for insulin glargine U-100.1,2,a,b
aOpened (in-use) Tresiba® should be refrigerated (36°F to 46°F [2°C to 8°C]) or kept at room temperature (below 86°F [30°C]), away from direct heat and light.1
bOpened (in-use) Lantus® SoloSTAR® device must be discarded 4 weeks after being opened. Once in use, the device must be kept at room temperature.2



Variety for patients who prefer vials1
- Contains 1000 total units
- Option for children who need fewer than 5 units per day
Once in use, the Tresiba® vial lasts 8 weeks, 2X as long as the insulin glargine U-100 vial, and 2 weeks longer than the insulin detemir vial.1-3,c,d
cIn-use Tresiba® can be kept at room temperature (below 86°F), away from direct heat and light, or refrigerated (36°F-46°F).
dThe in-use insulin glargine U-100 vial must be discarded after 4 weeks and the in-use insulin detemir vial must be discarded after 6 weeks.2,3

Conversations with caregivers and patients after a diabetes diagnosis
Below are some ways to address concerns caregivers may have about diabetes and basal insulin therapy. Use these talking points as you navigate through tough conversations following diagnosis.

Injecting
Addressing fears about needles:
- Tresiba® uses NovoFine® Plus needles, the shortest and thinnest available from Novo Nordisk
- Advise caregivers to create a calm environment, maybe a favorite show on a tablet can help
- Don't rush or seem anxious, but make the injection as fast as possible. Slower is not better

Diet
Encouraging healthy eating:
- Suggest that caregivers focus on balance, framing talks about diet in a way that allows for creativity and choice
- Remind caregivers that eating balanced meals isn’t a punishment for children, it’s something everyone should be doing

Exercise
Advocating for regular activity:
- Remind caregivers to leverage their child’s natural curiosity, taking them on a walk or to the park
- Encourage kids to play sports, but be sure to educate others on the signs of hypoglycemia and carry snacks or glucose tablets in case the child's blood sugar gets too low

Forming Healthy Habits
Being a role model:
- Encourage parents to get involved in routines and keep a positive attitude
- Advise parents and caretakers to reward or recognize healthy habits
