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Why choose Tresiba® FlexTouch® U-100?

When prescribing basal insulin, did you know you have another U-100 option? Watch this video to find out why Tresiba® FlexTouch® U-100 may be a more appropriate option for your patients 1 year of age and older with diabetes.  

Tresiba® FlexTouch® U-100

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Tresiba® comes in 3 administration options

Tresiba® FlexTouch® U‑1001

The U-100 you're familiar with
U-100 Green Injector

Pen contains 300 total units 


Delivers a maximum dose of 80 units in a single injection


1-unit dose adjustments


No push-button extension

Tresiba® FlexTouch®
U‑2001

Same dose in half the volume of U-100
U200 Dark Green Injector

Pen contains 600 total units


Up to 160 units in a single injection


2-unit dose adjustments


No push-button extension

Tresiba® U-100 10-mL vial1

For patients who prefer vials
U100 Vial

Vial contains 1000 total units


An option for children who need fewer than 5 units daily

Unit dosing remains the same, no matter which administration option you prescribe

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Tresiba® has one of the longest in-use times of any once-daily, long-acting basal insulin1-4

FlexTouch® Timing Chart

aOpened (in-use) Tresiba® should be refrigerated (36°F to 46°F [2°C to 8°C]) or kept at room temperature (below 86°F [30°C]), away from direct heat and light.1

bOpened (in-use) Lantus® SoloSTAR® devices must be discarded 4 weeks after being opened. Once in use, the device must be kept at room temperature and should not be refrigerated.2

cThe in-use insulin glargine U-100 vial must be discarded after 4 weeks and the in-use insulin detemir pen and vial must be discarded after 6 weeks.2,3

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View the Instructions For Use video and see how to get your patients started on once-daily dosing

Watch videos, read articles, and see what experts in the field are saying about Tresiba®

Selected Important Safety Information

Contraindications

  • Tresiba® is contraindicated during episodes of hypoglycemia and in patients with hypersensitivity to Tresiba® or one of its excipients

Warnings and Precautions

  • Never Share a Tresiba® FlexTouch® Pen, Needle, or Syringe Between Patients, even if the needle is changed. Patients using Tresiba® vials should never share needles or syringes with another person. Sharing poses a risk for transmission of blood-borne pathogens
  • Monitor blood glucose in all patients treated with insulin. Changes in insulin may affect glycemic control. These changes should be made cautiously and under medical supervision. Adjustments in concomitant anti-diabetic treatment may be needed
  • Hypoglycemia is the most common adverse reaction of insulin, including Tresiba®, and may be life-threatening

Indications and Usage

Tresiba® (insulin degludec injection) is indicated to improve glycemic control in patients 1 year of age and older with diabetes mellitus.

Limitations of Use

Tresiba® is not recommended for treating diabetic ketoacidosis.

Important Safety Information

Contraindications

  • Tresiba® is contraindicated during episodes of hypoglycemia and in patients with hypersensitivity to Tresiba® or one of its excipients

Warnings and Precautions

  • Never Share a Tresiba® FlexTouch® Pen, Needle, or Syringe Between Patients, even if the needle is changed. Patients using Tresiba® vials should never share needles or syringes with another person. Sharing poses a risk for transmission of blood-borne pathogens
  • Monitor blood glucose in all patients treated with insulin. Changes in insulin may affect glycemic control. These changes should be made cautiously and under medical supervision. Adjustments in concomitant anti-diabetic treatment may be needed
  • Hypoglycemia is the most common adverse reaction of insulin, including Tresiba®, and may be life-threatening. Increase monitoring with changes to: insulin dose, co-administered glucose lowering medications, meal pattern, physical activity; and in patients with hypoglycemia unawareness or renal or hepatic impairment
  • Accidental mix-ups between basal insulin products and other insulins, particularly rapid-acting insulins, have been reported. To avoid medication errors, always instruct patients to check the insulin label before each injection
  • Severe, life-threatening, generalized allergy, including anaphylaxis, can occur with insulin products, including Tresiba®
  • As with all insulins, Tresiba® use can lead to life-threatening hypokalemia, which then may cause respiratory paralysis, ventricular arrhythmia, and death. Closely monitor potassium levels in patients at risk of hypokalemia and treat if indicated
  • Fluid retention and heart failure can occur with concomitant use of thiazolidinediones (TZDs), which are PPAR-gamma agonists, and insulin, including Tresiba®. Patients should be observed for signs and symptoms of heart failure. If heart failure occurs, dosage reduction or discontinuation of the TZD must be considered

Adverse Reactions

  • Adverse reactions commonly associated with Tresiba® are hypoglycemia, allergic reactions, injection site reactions, lipodystrophy, pruritus, rash, edema, and weight gain

Drug Interactions

  • There are certain drugs that may cause clinically significant drug interactions with Tresiba®.
    • Drugs that may increase the risk of hypoglycemia: antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors, and SGLT-2 inhibitors
    • Drugs that may decrease the blood glucose lowering effect: atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones
    • Drugs that may increase or decrease the blood glucose lowering effect: alcohol, beta-blockers, clonidine, lithium salts, and pentamidine
    • Drugs that may blunt the signs and symptoms of hypoglycemia: beta-blockers, clonidine, guanethidine, and reserpine

Please click here for Prescribing Information

 

 

References:

  1. Tresiba [package insert]. Plainsboro, NJ: Novo Nordisk Inc; November 2018.
  2. Lantus [package insert]. Bridgewater, NJ: sanofi-aventis US LLC; November 2018.
  3. Levemir [package insert]. Plainsboro, NJ: Novo Nordisk Inc; January 2019.
  4. Basaglar [package insert]. Indianapolis, IN: Lilly USA LLC; June 2016.